Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ

Abstract excerpt

Abstract Myoepithelial cells play key roles in normal mammary gland development and in limiting pre-invasive to invasive breast tumor progression, yet their differentiation and perturbation in ductal carcinoma in situ (DCIS) are poorly understood. Here, we investigated myoepithelial cells in normal breast tissues ofBRCA1andBRCA2germline mutation carriers and in non-carrier controls, and in sporadic DCIS. We found...

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