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Article

Regulation of in situ to invasive breast carcinoma transition.

Cancer cell - 1 May 2008

Hu Min, Yao Jun, Carroll Danielle K, Weremowicz Stanislawa, Chen Haiyan, Carrasco Daniel, Richardson Andrea, Violette Shelia, Nikolskaya Tatiana, Nikolsky Yuri, Bauerlein Erica L, Hahn William C, Gelman Rebecca S, Allred Craig, Bissell Mina J, Schnitt Stuart, Polyak Kornelia

Abstract excerpt

The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors. Progression to invasion was promoted by fibroblasts and inhibited by normal myoepithelial cells. Molecular profiles of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18455123
DOI: 10.1016/j.ccr.2008.03.007
PMCID: PMC3705908

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