Article
Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.
The Journal of biological chemistry - 12 Dec 2003
Casarosa Paola, Gruijthuijsen Yvonne K, Michel Detlef, Beisser Patrick S, Holl Jens, Fitzsimons Carlos P, Verzijl Dennis, Bruggeman Cathrien A, Mertens Thomas, Leurs Rob, Vink Cornelis, Smit Martine J
Abstract excerpt
The human cytomegalovirus (HCMV) UL33 gene is conserved among all beta-herpesviruses and encodes a protein that shows sequence similarity with chemokine receptors belonging to the family of G protein-coupled receptors. Here, we show that HCMV UL33 is predominantly transcribed as a spliced mRNA of which the 5' terminus is localized 55 bp upstream of the start codon. Like its homolog from rat cytomegalovirus...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- COS Cells
- Cell Line, Tumor
- Cells, Cultured
- Codon
- Cyclic AMP Response Element Modulator
- DNA, Complementary