Article

Rete Ridge Topography as a Determinant of Epidermal Stem Cell Identity: Implications for Skin Aging

2026-04-14

Abstract excerpt

<title>Abstract</title> <p>Stem cell niches are dynamic microenvironments that regulate tissue homeostasis. Epidermal stem cells (EpiSC) preferentially localize to concave regions of epidermal rete ridges, which serve as primary niches for stem cell maintenance. EpiSC number and functional integrity decline during chronological aging. A defining feature of aged skin is epidermal atrophy, in which the prominent re...

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Literature Corpus work: 413ae78d-1a36-5540-90b4-cbcbabc731f7
DOI: 10.21203/rs.3.rs-9359924/v1

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