Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres.

Abstract excerpt

Organ homeostasis and organismal survival are related to the ability of stem cells to sustain tissue regeneration. As a consequence of accelerated telomerase shortening, telomerase-deficient mice show defective tissue regeneration and premature death. This suggests a direct impact of telomere length and telomerase activity on stem cell biology. We recently found that short telomeres impair the ability of...

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