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Toward a Scalable Purification Protocol of GaLV-TR-Pseudotyped Lentiviral Vectors

13 Sept 2019

Abstract excerpt

Lentiviral vectors (LV) that are used in research and development as well as in clinical trials are in majority vesicular stomatitis virus G glycoprotein (VSVg) pseudotyped. The predominance of this pseudotype choice for clinical gene therapy studies is largely due to a lack of purification schemes for pseudotypes other than VSVg. In this study, we report for the first time the development of a new downstream...

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PMID: 31516018
DOI: 10.1089/hgtb.2019.076

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