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Article

Acquisition of the rheumatoid arthritis HLA shared epitope through microchimerism.

Arthritis and rheumatism - 1 Mar 2011

Yan Zhen, Aydelotte Tessa, Gadi V K, Guthrie Katherine A, Nelson J Lee

Abstract excerpt

OBJECTIVE: HLA-DRB1 alleles associated with risk of rheumatoid arthritis (RA) encode similar HLA-DRB1 sequences, called the shared epitope (SE). The most common SE sequences are QKRAA and QRRAA. Nevertheless, a substantial number of RA patients lack the SE. Bidirectional fetal-maternal trafficking results in long-term persistence of fetal cells in the mother and maternal cells in her offspring, a process known as...

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Topics

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Share to Arthritis, Rheumatoid
Share to Chimerism
Share to Epitopes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DRB1 Chains

Share to Leukocytes, Mononuclear

Share to Maternal-Fetal Exchange

Share to Prevalence

Share to Real-Time Polymerase Chain Reaction

Source

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Identifiers

PMID: 21360493
DOI: 10.1002/art.30160
PMCID: PMC3188444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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