Article
Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders.
Molecular psychiatry - 1 Apr 2021
Rao Xi, Thapa Kriti S, Chen Andy B, Lin Hai, Gao Hongyu, Reiter Jill L, Hargreaves Katherine A, Ipe Joseph, Lai Dongbing, Xuei Xiaoling, Wang Yue, Gu Hongmei, Kapoor Manav, Farris Sean P, Tischfield Jay, Foroud Tatiana, Goate Alison M, Skaar Todd C, Mayfield R Dayne, Edenberg Howard J, Liu Yunlong
Abstract excerpt
Genome-wide association studies (GWAS) of complex traits, such as alcohol use disorders (AUD), usually identify variants in non-coding regions and cannot by themselves distinguish whether the associated variants are functional or in linkage disequilibrium with the functional variants. Transcriptome studies can identify genes whose expression differs between alcoholics and controls. To test which variants...
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