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DNA repair in cancer initiation, progression, and therapy—a double-edged sword

30 Aug 2019

Abstract excerpt

Genomic and mitochondrial DNA molecules are exposed continuously for a damaging activity of chemical, physical, and internal genotoxicants. When DNA repair machinery is not working efficiently, the generation of DNA lesions and mutations leads to carcinogenic transformation. The high number of mutation going up to 10 5 per cell was recognized as a driving force of oncogenesis. Moreover, a high activity of DNA...

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PMID: 31468363
DOI: 10.1007/s13353-019-00516-9

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