Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

9 Jul 2021

Abstract excerpt

Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers. However, the adverse effects including normal tissues injury are also accompanied by the radiotherapy and chemotherapy. Targeted cancer therapy has the potential to suppress cancer cells' DNA...

Topics

Join the communities discussing this publication.

Cell death mechanisms and regulation
DNA Repair Mechanisms
PARP inhibition in cancer therapy

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34238917
DOI: 10.1038/s41392-021-00648-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapyPMID 34238917Read ↗

DNA Damage and Its Role in Cancer Therapeutics.Semantic proximity Read ↗

Role of DNA damage and repair in radiation cancer therapy: a current update and a look to the futureSemantic proximity Read ↗

Repurposing DNA repair factors to eradicate tumor cells upon radiotherapySemantic proximity Read ↗

DNA damage response, genetic instability and cancer: From mechanistic insights to personalized treatmentSemantic proximity Read ↗

Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer TherapiesSemantic proximity Read ↗

DNA Damage and Repair: From Molecular Mechanisms to Health ImplicationsSemantic proximity Read ↗

DNA repair in cancer initiation, progression, and therapy—a double-edged swordSemantic proximity Read ↗

A brief history of the DNA repair field.Semantic proximity Read ↗

Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapySemantic proximity Read ↗

The accumulation of DNA repair defects is the molecular origin of carcinogenesis.Semantic proximity Read ↗

The two faces of DNA repair: disease and therapy.Semantic proximity Read ↗

Tissue Specificity of DNA Damage and RepairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.