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DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

9 Jul 2021

Abstract excerpt

Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers. However, the adverse effects including normal tissues injury are also accompanied by the radiotherapy and chemotherapy. Targeted cancer therapy has the potential to suppress cancer cells' DNA...

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PMID: 34238917
DOI: 10.1038/s41392-021-00648-7

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