Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paradoxical Impact of Two Folate Receptors, FRα and RFC, in Ovarian Cancer: Effect on Cell Proliferation, Invasion and Clinical Outcome

7 Nov 2012

Abstract excerpt

Despite being an essential vitamin, folate has been implicated to enhance tumor growth, as evidenced by reports on overexpression of folate receptor alpha (FRα) in carcinomas. The role of another folate transporter, reduced folate carrier (RFC), is largely unknown. This study investigated the roles of folate, FRα and RFC in ovarian cancers. We demonstrated FRα mRNA and protein overexpression and reduced RFC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Folate and B Vitamins Research
Share to Pregnancy and preeclampsia studies
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23144806
DOI: 10.1371/journal.pone.0047201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paradoxical Impact of Two Folate Receptors, FRα and RFC, in Ovarian Cancer: Effect on Cell Proliferation, Invasion and Clinical OutcomePMID 23144806Read ↗

Folate Receptor Alpha in Advanced Epithelial Ovarian Cancer: Diagnostic Role and Therapeutic Implications of a Clinically Validated BiomarkerSemantic proximity Read ↗

Folate receptor alpha protein expression in ovarian serous cystadenocarcinoma tumors of The Cancer Genome Atlas: exploration beyond single-agent therapySemantic proximity Read ↗

Correlation of folate receptor alpha expression with clinicopathological parameters and outcome in triple negative breast cancer.Semantic proximity Read ↗

Role of the folate receptor in ovarian cancer treatment: evidence, mechanism, and clinical implicationsSemantic proximity Read ↗

High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation.Semantic proximity Read ↗

The Folate Receptor α Is Frequently Overexpressed in Osteosarcoma Samples and Plays a Role in the Uptake of the Physiologic Substrate 5-MethyltetrahydrofolateSemantic proximity Read ↗

The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander?Semantic proximity Read ↗

Role of folate receptor genes in reproduction and related cancersSemantic proximity Read ↗

FRα expression in advanced endometrial carcinoma: Clinicopathological, molecular, and prognosis correlates.Semantic proximity Read ↗

Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implicationsSemantic proximity Read ↗

Emerging roles for folate receptor FOLR1 in signaling and cancerSemantic proximity Read ↗

Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.