Article
Macrophage migration inhibitory factor elicits an angiogenic phenotype in human ectopic endometrial cells and triggers the production of major angiogenic factors via CD44, CD74, and MAPK signaling pathways.
The Journal of clinical endocrinology and metabolism - 1 Dec 2010
Veillat Véronique, Carli Cédric, Metz Christine N, Al-Abed Yousef, Naccache Paul H, Akoum Ali
Abstract excerpt
CONTEXT: An active angiogenesis is required for ectopic endometrial tissue growth. Our previous studies led to the identification of macrophage migration inhibitory factor (MIF), which is markedly elevated in active, vascularized, and early-stage endometriotic lesions, as a potent mitogenic factor for endothelial cells. OBJECTIVE: Our objective was to study the mechanisms by which MIF may stimulate angiogenesis...
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