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Article

Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints

26 Aug 2019

Abstract excerpt

Introduction: Molecular analyzes including molecular descriptor/phenotype interactions have led to better characterization of epithelial ovarian cancer patients, including a definition of a BRCA wild-type (BRCAwt) phenotype. Understanding how and when to use agents targeted against dependent BRCAwt pathways or other molecular events at disease progression is an important translational and therapeutic direction in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31449760
DOI: 10.1080/13543784.2019.1657403

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