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BRCAness: Finding the Achilles Heel in Ovarian Cancer

6 Jun 2012

Abstract excerpt

Ovarian cancer is the leading cause of death among gynecological cancers. It exhibits great heterogeneity in tumor biology and treatment response. Germline mutations of DNA repair genes BRCA1/2 are the fundamental defects in hereditary ovarian cancer that expresses a distinct phenotype of high response rates to platinum agents, improved disease-free intervals and survival rates, and high-grade serous histology....

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PMID: 22673632
DOI: 10.1634/theoncologist.2012-0028

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