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Article

Mutations in γ-secretase subunit-encoding PSENEN gene alone may not be sufficient for the development of acne inversa.

Journal of dermatological science - 1 Aug 2021

Zhou Pengjun, Liu Jingjing, Xu Tianxing, Guo Yanni, Han Yue, He Yanyan, Lin Lihang, Xiao Xuemin

Abstract excerpt

BACKGROUND: The effects of PSENEN mutations in patients with acne inversa (AI) are poorly understood. Hyperproliferation of follicular keratinocytes and resulting occlusion may constitute the initial pathophysiology. OBJECTIVE: To investigate the effects of PSENEN knockdown on γ-secretase subunits, biological behaviors, and related signaling pathways in keratinocytes. METHODS: HaCaT cells were divided into an...

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PMID: 34330582
DOI: 10.1016/j.jdermsci.2021.06.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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