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Article

Nicastrin/miR-30a-3p/RAB31 Axis Regulates Keratinocyte Differentiation by Impairing EGFR Signaling in Familial Acne Inversa.

The Journal of investigative dermatology - 1 Jan 2019

He Yanyan, Xu Haoxiang, Li Chengrang, Zhang Xiaofeng, Zhou Pengjun, Xiao Xuemin, Zhang Wanlu, Wu Yingda, Zeng Rong, Wang Baoxi

Abstract excerpt

Nicastrin (NCSTN) mutations are associated with familial acne inversa (AI), and emerging evidence suggests that microRNAs (miRNAs) are involved in various skin diseases. However, whether NCSTN mutations affect miRNA levels and their subsequent signaling pathways in familial AI patients has not been studied. We aimed to elucidate the relationship between NCSTN mutations and familial AI pathogenesis by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30120935
DOI: 10.1016/j.jid.2018.07.020

Genes

NCSTN
EGFR
RAB31

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nicastrin/miR-30a-3p/RAB31 Axis Regulates Keratinocyte Differentiation by Impairing EGFR Signaling in Familial Acne Inversa.PMID 30120935Read ↗

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