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Is generation of C3(H2O) necessary for activation of the alternative pathway in real life?

22 Aug 2019

Abstract excerpt

In the alternative pathway (AP) an amplification loop is formed, which is strictly controlled by various fluid-phase and cell-bound regulators resulting in a state of homeostasis. Generation of the “C3b-like” C3(H2O) has been described as essential for AP activation, since it conveniently explains how the initial fluid-phase AP convertase of the amplification loop is generated. Also, the AP has a status of being...

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PMID: 31446306
DOI: 10.1016/j.molimm.2019.07.032

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