The complement alternative pathway in health and disease—activation or amplification?

Abstract excerpt

In late 2020, one of us (RAH) was approached by the late Professor Sir Peter Lachmann and invited to join him in co-editing a collection of articles focused on the alternative pathway (AP), or amplification loop (AL), of C3 activation. He had recognized that much had changed since his first proposal of “C3 tickover.” New controversies had arisen, significant advances in our understanding of complement involvement...

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