Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence

23 Aug 2019

Abstract excerpt

Defective macroautophagy/autophagy and mitochondrial dysfunction are known to stimulate senescence. The mitochondrial regulator PPARGC1A (peroxisome proliferator activated receptor gamma, coactivator 1 alpha) regulates mitochondrial biogenesis, reducing senescence of vascular smooth muscle cells (VSMCs); however, it is unknown whether autophagy mediates PPARGC1A-protective effects on senescence. Using ppargc1a−/-...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Glycation End Products research
Share to Autophagy in Disease and Therapy
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31441382
DOI: 10.1080/15548627.2019.1659612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescencePMID 31441382Read ↗

Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis.Semantic proximity Read ↗

p62/ SQSTM1 and Selective Autophagy in Cardiometabolic DiseasesSemantic proximity Read ↗

Defective Autophagy in Atherosclerosis: To Die or to Senesce?Semantic proximity Read ↗

Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Is a Central Negative Regulator of Vascular SenescenceSemantic proximity Read ↗

Implications of autophagy for vascular smooth muscle cell function and plasticitySemantic proximity Read ↗

Autophagy and cardiovascular agingSemantic proximity Read ↗

Vascular Cell SenescenceSemantic proximity Read ↗

Protective role of chaperone-mediated autophagy against atherosclerosisSemantic proximity Read ↗

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress.Semantic proximity Read ↗

Contribution of p62 to Phenotype Transition of Coronary Arterial Myocytes with Defective Autophagy.Semantic proximity Read ↗

Obesity and type-2 diabetes as inducers of premature cellular senescence and ageingSemantic proximity Read ↗

Vascular smooth muscle cell senescence in atherosclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.