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Article

Mesenchymal stem cells maintain their defining stem cell characteristics after treatment with cisplatin.

Scientific reports - 25 Jan 2016

Nicolay Nils H, Lopez Perez Ramon, Rühle Alexander, Trinh Thuy, Sisombath Sonevisay, Weber Klaus-Josef, Ho Anthony D, Debus Jürgen, Saffrich Rainer, Huber Peter E

Abstract excerpt

Mesenchymal stem cells (MSCs) aid the regeneration of tissues damaged by treatment with cisplatin. However, the effects of this cytotoxic drug on the stem cells have been largely unknown. Here we demonstrate that human bone marrow-derived MSCs are relatively resistant to cisplatin treatment and show resistance levels comparable to these of differentiated fibroblasts. Cisplatin did not affect cellular morphology,...

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Source

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Identifiers

PMID: 26805490
DOI: 10.1038/srep20035
PMCID: PMC4726328

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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