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Article

Chemotherapy-induced genotoxic damage to bone marrow cells: long-term implications

1 May 2018

Abstract excerpt

Mesenchymal stem/stromal cells (MSCs) within the bone marrow (BM) are vitally important in forming the micro-environment supporting haematopoiesis after myeloablative chemotherapy. MSCs are known to be damaged phenotypically and functionally by chemotherapy; however, to the best our knowledge, the persistence of genotoxic effects of chemotherapy on the BM micro-environment has not been studied. We therefore aimed...

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PMID: 30239865
DOI: 10.1093/mutage/gey014

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