Article
Presence of mesenchymal stem cells in human bone marrow after exposure to chemotherapy: evidence of resistance to apoptosis induction.
Stem cells (Dayton, Ohio) - 1 Dec 2006
Mueller Lutz P, Luetzkendorf Jana, Mueller Thomas, Reichelt Katrin, Simon Heike, Schmoll Hans-Joachim
Abstract excerpt
For various potential clinical applications, the use of autologous human MSCs (hMSCs) would be favorable. In vitro observations suggested that hMSCs are resistant for chemotherapeutic substances; however, no data exist on the characteristics of hMSCs from bone marrow (BM) of chemotherapeutically treated patients. Here, we analyzed the character of hMSCs derived from chemotherapy-exposed BM and the in vitro...
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