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Article

ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells

21 Aug 2019

Abstract excerpt

Abstract Glioblastomas (GBM) are lethal brain tumors where poor outcome is attributed to cellular heterogeneity, therapeutic resistance, and a highly infiltrative nature. These characteristics are preferentially linked to GBM cancer stem cells (GSC), but how GSCs maintain their stemness is incompletely understood and the subject of intense investigation. Here, we identify a novel signaling loop that induces and...

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PMID: 31434712
DOI: 10.1158/2159-8290.cd-18-1308

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