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Matrix metalloproteinases in stem cell regulation and cancer

3 Feb 2015

Abstract excerpt

Since Gross and Lapiere firstly discovered matrix metalloproteinases (MMPs) as important collagenolytic enzymes during amphibian tadpole morphogenesis in 1962, this intriguing family of extracellular proteinases has been implicated in various processes of developmental biology. However, the pathogenic roles of MMPs in human diseases such as cancer have also garnered widespread attention. The most straightforward...

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PMID: 25661772
DOI: 10.1016/j.matbio.2015.01.022

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