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A novel program of infiltrative control in astrocytomas: ADAM23 depletion promotes cell invasion by activating γ-Secretase and NOTCH1 signaling pathway

2022-05-12

Abstract excerpt

<h4>Background: </h4> Diffuse infiltration is a life-threatening growth pattern in malignant astrocytomas and a significant cause of therapy resistance. This pattern is determined by the balance between proliferative and invasive genetic programs and is mainly recapitulated by glioma stem cells (GSCs) during astrocytoma progression. Infiltration results in the GSCs spreading deeply into the surrounding brain tissu...

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Literature Corpus work
42248992-2676-5aed-851c-7c631b8d2d5e
DOI
10.21203/rs.3.rs-1538484/v1
Open publication

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A novel program of infiltrative control in astrocytomas: ADAM23 depletion promotes cell invasion by activating γ-Secretase and NOTCH1 signaling pathwayDOI 10.21203/rs.3.rs-1538484/v1
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