Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of <i>hTERT</i> and <i>p16</i> expression

Abstract excerpt

Cancer cells metabolize glucose at elevated rates and have a higher sensitivity to glucose reduction. However, the precise molecular mechanisms leading to different responses to glucose restriction between normal and cancer cells are not fully understood. We analyzed normal WI-38 and immortalized WI-38/S fetal lung fibroblasts and found that glucose restriction resulted in growth inhibition and apoptosis in...

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