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Article

A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.

PLoS genetics - 1 Aug 2019

Lang Sven, Hilsabeck Tyler A, Wilson Kenneth A, Sharma Amit, Bose Neelanjan, Brackman Deanna J, Beck Jennifer N, Chen Ling, Watson Mark A, Killilea David W, Ho Sunita, Kahn Arnold, Giacomini Kathleen, Stoller Marshall L, Chi Thomas, Kapahi Pankaj

Abstract excerpt

Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones. Despite frequent occurrence of these disorders, the genetic pathways influencing UA metabolism and the association with disease remain poorly understood. In humans, elevated UA levels resulted from the loss of the of the urate oxidase (Uro) gene around 15 million years ago. Therefore, we...

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Identifiers

PMID: 31415568
DOI: 10.1371/journal.pgen.1008318
PMCID: PMC6695094

Genes

AKT2
FOXO3

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