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Article

Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's disease.

PloS one - 1 Jan 2013

Tabunoki Hiroko, Ono Hiromasa, Ode Hiroaki, Ishikawa Kazuhiro, Kawana Natsuki, Banno Yutaka, Shimada Toru, Nakamura Yuki, Yamamoto Kimiko, Satoh Jun-Ichi, Bono Hidemasa

Abstract excerpt

Plasma uric acid (UA) levels decrease following clinical progression and stage development of Parkinson's disease (PD). However, the molecular mechanisms underlying decreases in plasma UA levels remain unclear, and the potential to apply mutagenesis to a PD model has not previously been discovered. We identified a unique mutant of the silkworm Bombyx mori (B.mori) op. Initially, we investigated the causality of...

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PMID: 23894418
DOI: 10.1371/journal.pone.0069130
PMCID: PMC3722175

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Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's disease.PMID 23894418Read ↗

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