Article

A conserved role of the insulin-like signaling pathway in uric acid pathologies revealed in <i>Drosophila melanogaster</i>

2018-08-09

Abstract excerpt

<h4>Summary</h4> Elevated uric acid (UA) is a key factor for disorders, including gout or kidney stones and result from abrogated expression of Urate Oxidase (Uro) and diet. To understand the genetic pathways influencing UA metabolism we established a Drosophila melanogaster model with elevated UA using Uro knockdown. Reduced Uro expression resulted in the accumulation of UA concretions and diet-dependent sho...

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Literature Corpus work: 2126ef48-3867-519b-9994-e7010574612e
DOI: 10.1101/387779

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