Genetics of susceptibility to Plasmodium falciparum: from classical malaria resistance genes towards genome-wide association studies.

doi:10.1111/j.1365-3024.2009.01106.x

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Article

Genetics of susceptibility to Plasmodium falciparum: from classical malaria resistance genes towards genome-wide association studies.

Parasite immunology - 1 May 2009

Verra F, Mangano V D, Modiano D

Abstract excerpt

Plasmodium falciparum represents one of the strongest selective forces on the human genome. This stable and perennial pressure has contributed to the progressive accumulation in the exposed populations of genetic adaptations to malaria. Descriptive genetic epidemiology provides the initial step of a logical procedure of consequential phases spanning from the identification of genes involved in the...

Topics

Animals
Erythrocytes
Genetic Predisposition to Disease
Genome, Human
Genome-Wide Association Study
Humans
Immunity
Malaria, Falciparum
Plasmodium falciparum
Polymorphism, Genetic
Proteins

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PMID: 19388945
DOI: 10.1111/j.1365-3024.2009.01106.x

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