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Genome-wide brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease

25 Jun 2019

Abstract excerpt

OBJECTIVE: Given the known strong relationship of DNA methylation with environmental exposure, we investigated whether brain regions affected in Parkinson disease (PD) were differentially methylated between PD cases and controls. METHODS: DNA chip arrays were used to perform a genome-wide screen of DNA methylation on the dorsal motor nucleus of the vagus (DMV), substantia nigra (SN), and cingulate gyrus (CG) of...

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PMID: 31403079
DOI: 10.1212/nxg.0000000000000342

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