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Article

JAK2 Variant Signaling: Genetic, Hematologic and Immune Implication in Chronic Myeloproliferative Neoplasms.

Biomolecules - 11 Feb 2022

Torres Dania G, Paes Jhemerson, da Costa Allyson G, Malheiro Adriana, Silva George V, Mourão Lucivana P de Souza, Tarragô Andréa M

Abstract excerpt

The JAK2V617F variant constitutes a genetic alteration of higher frequency in BCR/ABL1 negative chronic myeloproliferative neoplasms, which is caused by a substitution of a G ˃ T at position 1849 and results in the substitution of valine with phenylalanine at codon 617 of the polypeptide chain. Clinical, morphological and molecular genetic features define the diagnosis criteria of polycythemia vera, essential...

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Janus Kinase 2
Kruppel-like factors research
Mutation
Myeloproliferative Disorders
Myeloproliferative Neoplasms: Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycythemia Vera

Signal Transduction

Thrombocythemia, Essential

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Identifiers

PMID: 35204792
DOI: 10.3390/biom12020291
PMCID: PMC8961666

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