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Article

Cigarette smoke activates the parthanatos pathway of cell death in human bronchial epithelial cells

5 Aug 2019

Abstract excerpt

Tobacco smoke negatively affects human bronchial epithelial (HBE) cells and is directly implicated in the etiology of smoking related respiratory diseases. Smoke exposure causes double-stranded DNA breaks and DNA damage activates PARP-1, the key mediator of the parthanatos pathway of cell death. We hypothesize that smoke exposure activates the parthanatos pathway in HBE cells and represents a cell death mechanism...

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PMID: 31396404
DOI: 10.1038/s41420-019-0205-3

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