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Article

Chronic cigarette smoke extract treatment selects for apoptotic dysfunction and mitochondrial mutations in minimally transformed oral keratinocytes.

International journal of cancer - 1 Jan 2010

Chang Steven S, Jiang Wei Wen, Smith Ian, Glazer Chad, Sun Wen-Yue, Mithani Suhail, Califano Joseph A

Abstract excerpt

Cigarette smoke demonstrates a carcinogenic effect through chronic exposure, not acute exposures. However, current cell line models study only the acute effects of cigarette smoke. Using a cell line model, we compared the effects of acute versus chronic cigarette smoke extract (CSE) on mitochondria in minimally transformed oral keratinocytes (OKF6). OKF6 cells were treated with varying concentrations of CSE for 6...

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Identifiers

PMID: 19634139
DOI: 10.1002/ijc.24777
PMCID: PMC2818069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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