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Circularization of flavivirus genomic RNA inhibits de novo translation initiation

27 Jul 2019

Abstract excerpt

Members of the Flaviviridae family, including dengue virus (DENV) and yellow fever virus, cause serious disease in humans, whilst maternal infection with Zika virus (ZIKV) can induce microcephaly in newborns. Following infection, flaviviral RNA genomes are translated to produce the viral replication machinery but must then serve as a template for the transcription of new genomes. However, the ribosome and viral...

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PMID: 31392996
DOI: 10.1093/nar/gkz686

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