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The flavivirus polymerase NS5 regulates translation of viral genomic RNA

2 Apr 2020

Abstract excerpt

Flaviviruses, including dengue virus and Zika virus, contain a single-stranded positive sense RNA genome that encodes viral proteins essential for replication and also serves as the template for new genome synthesis. As these processes move in opposite directions along the genome, translation must be inhibited at a defined point following infection to clear the template of ribosomes to allow efficient...

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PMID: 32313955
DOI: 10.1093/nar/gkaa242

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