Article
Virulence and Cross-Protection Conferred by an Attenuated Genotype I-Based Chimeric Japanese Encephalitis Virus Strain Harboring the E Protein of Genotype V in Mice.
Microbiology spectrum - 21 Dec 2022
Xia Qiqi, Zhang Yan, Yang Yang, Ma Xiaochun, Guan Zhixin, Zhang Junjie, Li Zongjie, Liu Ke, Li Beibei, Shao Donghua, Qiu Yafeng, Wei Jianchao, Ma Zhiyong
Abstract excerpt
Japanese encephalitis virus (JEV) genotype V (GV) emerged in China in 2009, then South Korea, and has since spread to other regions in Asia and beyond, raising concern about its pathogenicity and the cross-protection offered by JEV vaccines against different genotypes. In this study, we replaced the structural proteins (C-prM-E) of an attenuated genotype I (GI) SD12-F120 strain with those of a virulent GV XZ0934...
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