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Genotype I of Japanese Encephalitis Virus Virus-like Particles Elicit Sterilizing Immunity against Genotype I and III Viral Challenge in Swine.

Scientific reports - 10 May 2018

Fan Yi-Chin, Chen Jo-Mei, Lin Jen-Wei, Chen Yi-Ying, Wu Guan-Hong, Su Kuan-Hsuan, Chiou Ming-Tang, Wu Shang-Rung, Yin Ji-Hang, Liao Jiunn-Wang, Chang Gwong-Jen J, Chiou Shyan-Song

Abstract excerpt

Swine are a critical amplifying host involved in human Japanese encephalitis (JE) outbreaks. Cross-genotypic immunogenicity and sterile protection are important for the current genotype III (GIII) virus-derived vaccines in swine, especially now that emerging genotype I (GI) JE virus (JEV) has replaced GIII virus as the dominant strain. Herein, we aimed to develop a system to generate GI JEV virus-like particles...

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Identifiers

PMID: 29748549
DOI: 10.1038/s41598-018-25596-1
PMCID: PMC5945781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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