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Article

Low Protective Efficacy of the Current Japanese Encephalitis Vaccine against the Emerging Genotype 5 Japanese Encephalitis Virus.

PLoS neglected tropical diseases - 1 May 2016

Cao Lei, Fu Shihong, Gao Xiaoyan, Li Minghua, Cui Shiheng, Li Xiaolong, Cao Yuxi, Lei Wenwen, Lu Zhi, He Ying, Wang Huanyu, Yan Jinghua, Gao George Fu, Liang Guodong

Abstract excerpt

BACKGROUND: The current Japanese encephalitis (JE) vaccine derived from G3 JE virus (JEV) can induce protective immunity against G1-G4 JEV genotypes. However, protective efficacy against the emerging G5 genotype has not been reported. METHODS/PRINCIPAL FINDINGS: Using in vitro and in vivo tests, biological phenotype and cross-immunoreactions were compared between G3 JEV and G5 JEV (wild strains). The PRNT90...

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Identifiers

PMID: 27139722
DOI: 10.1371/journal.pntd.0004686
PMCID: PMC4854478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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