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Study on the Protective Efficacy of the Japanese Encephalitis Live Attenuated Vaccine SA14-14-2 Against Newly Isolated Genotype I Japanese Encephalitis Viruses.

Viruses - 21 May 2026

Shang Shuai, Yin Qikai, Che Tingyi, Wang Xinzhu, Su Qi, Fu Shihong, Xu Hongshan, Yu Yongxin, Mao Qunying, Wang Huanyu, Liu Xinyu

Abstract excerpt

Japanese encephalitis virus (JEV) comprises a single serotype but can be classified into five genotypes (genotypes I-V, GI-GV) based on nucleic acid sequences. Historically, genotype III (GIII) was the predominant strain. However, since the 21st century, genotype I (GI) rapidly replaced GIII as the major genotype in China, Southeast Asia, and other regions. The live attenuated vaccine (LAV) SA14-14-2, licensed in...

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PMID: 42198783
DOI: 10.3390/v18050582
PMCID: PMC13211682

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