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Dynamic chromatin accessibility tuning by the long noncoding RNA ELDR accelerates chondrocyte senescence and osteoarthritis

2 Mar 2023

Abstract excerpt

Epigenetic reprogramming plays a critical role in chondrocyte senescence during osteoarthritis (OA) pathology, but the underlying molecular mechanisms remain to be elucidated. Here, using large-scale individual datasets and genetically engineered (Col2a1-CreER T2 ; Eldr flox/flox and Col2a1-CreER T2 ; ROSA26 -LSL- Eldr +/+ knockin) mouse models, we show that a novel transcript of long noncoding RNA ELDR is...

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PMID: 36868238
DOI: 10.1016/j.ajhg.2023.02.011

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