Molecular Profiling Reclassifies Adult Astroblastoma into Known and Clinically Distinct Tumor Entities with Frequent Mitogen-Activated Protein Kinase Pathway Alterations

Abstract excerpt

Abstract Background Astroblastoma (ABM) is a rare glial brain tumor. Recurrent meningioma 1 (MN1) alterations have been recently identified in most pediatric cases. Adolescent and adult cases, however, remain molecularly poorly defined. Materials and Methods We performed clinical and molecular characterization of a retrospective cohort of 14 adult and 1 adolescent ABM. Results Strikingly, we found that MN1...

Topics

Join the communities discussing this publication.

• Brain Metastases and Treatment
• Glioma Diagnosis and Treatment
• Meningioma and schwannoma management