Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults.

doi:10.1093/neuonc/now118

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Article

Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults.

Neuro-oncology - 1 Jan 2017

Lehman Norman L, Hattab Eyas M, Mobley Bret C, Usubalieva Aisulu, Schniederjan Matthew J, McLendon Roger E, Paulus Werner, Rushing Elisabeth J, Georgescu Maria-Magdalena, Couce Marta, Dulai Mohanpal S, Cohen Mark L, Pierson Christopher R, Raisanen Jack M, Martin Sarah E, Lehman Trang D, Lipp Eric S, Bonnin Jose M, Al-Abbadi Mousa A, Kenworthy Kara, Zhao Kevin, Mohamed Nehad, Zhang Guojuan, Zhao Weiqiang

Abstract excerpt

BACKGROUND: Astroblastomas (ABs) are rare glial tumors showing overlapping features with astrocytomas, ependymomas, and sometimes other glial neoplasms, and may be challenging to diagnose. METHODS: We examined clinical, histopathological, and molecular features in 28 archival formalin-fixed, paraffin-embedded AB cases and performed survival analyses using Cox proportional hazards and Kaplan-Meier methods....

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Identifiers

PMID: 27416954
DOI: 10.1093/neuonc/now118
PMCID: PMC5193018

Genes

BRAF
MGMT

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