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Article

Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities.

Brain pathology (Zurich, Switzerland) - 1 Mar 2018

Wood Matthew D, Tihan Tarik, Perry Arie, Chacko Geeta, Turner Clinton, Pu Cunfeng, Payne Christopher, Yu Alexander, Bannykh Serguei I, Solomon David A

Abstract excerpt

Astroblastoma is a rare and controversial glioma with variable clinical behavior. The diagnosis currently rests on histologic findings of a circumscribed glioma with astroblastomatous pseudorosettes and vascular hyalinization. Immunohistochemical studies have suggested different oncogenic drivers, such as BRAF p.V600E, but very few cases have been studied using genome-wide methodologies. Recent genomic profiling...

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Source

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Identifiers

PMID: 28960623
DOI: 10.1111/bpa.12561
PMCID: PMC5843525

Genes

MN1
TERT
BRAF
CDKN2A
TP53
ATM
CDK4
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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