Globoside Is Dispensable for Parvovirus B19 Entry but Essential at a Postentry Step for Productive Infection

Abstract excerpt

Globoside has long been considered the primary receptor of B19V. However, its expression does not correlate well with B19V binding and uptake and cannot explain the pathogenesis or the remarkable narrow tissue tropism of the virus. By using a knockout cell line, we demonstrate that globoside does not have the expected function as a cell surface receptor required for B19V entry, but it has an essential role at a...

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