Article
The Receptor-Binding Domain in the VP1u Region of Parvovirus B19.
Viruses - 24 Feb 2016
Leisi Remo, Di Tommaso Chiarina, Kempf Christoph, Ros Carlos
Abstract excerpt
Parvovirus B19 (B19V) is known as the human pathogen causing the mild childhood disease erythema infectiosum. B19V shows an extraordinary narrow tissue tropism for erythroid progenitor cells in the bone marrow, which is determined by a highly restricted uptake. We have previously shown that the specific internalization is mediated by the interaction of the viral protein 1 unique region (VP1u) with a yet unknown...
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