Article
Erythrocyte P antigen: cellular receptor for B19 parvovirus.
Science (New York, N.Y.) - 1 Oct 1993
Brown K E, Anderson S M, Young N S
Abstract excerpt
The pathogenic human parvovirus B19 replicates only in erythroid progenitor cells. This virus was shown to bind to blood-group P antigen, as measured by hemagglutination. Erythrocytes lacking P antigen were not agglutinated with B19. Purified P antigen (globoside) blocked the binding of the virus to erythroid cells and the infectivity of the virus in a hematopoietic colony assay. Target cells were protected from...
Topics
- Antibodies, Monoclonal
- Capsid
- Carbohydrate Sequence
- Cytopathogenic Effect, Viral
- Erythrocyte Membrane
- Erythroid Precursor Cells
- Globosides
- Hemagglutination
- Humans
- Molecular Sequence Data
- P Blood-Group System