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Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus

23 Jul 2019

Abstract excerpt

Coronaviruses encode an exoribonuclease (ExoN) that is important for viral replication, fitness, and virulence, yet coronaviruses with a defective ExoN (ExoN-AA) have not reverted under diverse experimental conditions. In this study, we identify multiple impediments to MHV-ExoN-AA reversion. We show that ExoN-AA reversion is possible but evolutionarily unfavorable. Instead, compensatory mutations outside ExoN-AA...

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PMID: 31341046
DOI: 10.1128/jvi.00711-19

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