Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery of potential urine-accessible metabolite biomarkers associated with muscle disease and corticosteroid response in the mdx mouse model for Duchenne.

PloS one - 1 Jan 2019

Thangarajh Mathula, Zhang Aiping, Gill Kirandeep, Ressom Habtom W, Li Zhenzhi, Varghese Rency S, Hoffman Eric P, Nagaraju Kanneboyina, Hathout Yetrib, Boca Simina M

Abstract excerpt

Urine is increasingly being considered as a source of biomarker development in Duchenne Muscular Dystrophy (DMD), a severe, life-limiting disorder that affects approximately 1 in 4500 boys. In this study, we considered the mdx mice-a murine model of DMD-to discover biomarkers of disease, as well as pharmacodynamic biomarkers responsive to prednisolone, a corticosteroid commonly used to treat DMD. Longitudinal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, Liquid
Share to Creatine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysine

Share to Mice, Inbred mdx

Share to Muscular Dystrophy, Animal

Share to Muscular Dystrophy, Duchenne

Share to Prednisolone

Share to Principal Component Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 31310630
DOI: 10.1371/journal.pone.0219507
PMCID: PMC6634414

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery of potential urine-accessible metabolite biomarkers associated with muscle disease and corticosteroid response in the mdx mouse model for Duchenne.PMID 31310630Read ↗

Circulating Biomarkers for Duchenne Muscular DystrophySemantic proximity Read ↗

Identification of marker proteins of muscular dystrophy in the urine proteome from the mdx-4cv model of dystrophinopathySemantic proximity Read ↗

Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patientsSemantic proximity Read ↗

Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscleSemantic proximity Read ↗

Duchenne Muscular Dystrophy: recent advances in protein biomarkers and the clinical applicationSemantic proximity Read ↗

Dystrophinopathy-associated dysfunction of Krebs cycle metabolismSemantic proximity Read ↗

Multiomics Analysis of the mdx/mTR Mouse Model of Duchenne Muscular DystrophySemantic proximity Read ↗

Emerging proteomic biomarkers of X-linked muscular dystrophySemantic proximity Read ↗

Downregulation of miRNA-29, -23 and -21 in Urine of Duchenne Muscular Dystrophy PatientsSemantic proximity Read ↗

Cholesterol metabolism is a potential therapeutic target in Duchenne Muscular DystrophySemantic proximity Read ↗

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophySemantic proximity Read ↗

Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.