Article
Dcifer: an IBD-based method to calculate genetic distance between polyclonal infections.
Genetics - 30 Sept 2022
Gerlovina Inna, Gerlovin Boris, Rodríguez-Barraquer Isabel, Greenhouse Bryan
Abstract excerpt
An essential step toward reconstructing pathogen transmission and answering epidemiologically relevant questions from genomic data is obtaining pairwise genetic distance between infections. For recombining organisms such as malaria parasites, relatedness measures quantifying recent shared ancestry would provide a meaningful distance, suggesting methods based on identity by descent (IBD). While the concept of...
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